Prevention of disease is one of the key functions of primary care. Vaccines have earned their place in preventing communicable diseases. The rate of uptake of vaccines does not always match with knowledge. There are barriers which the healthcare professionals need to address. In the new era of IT, innovation and policy change, many ideas can be pursued to improve vaccination uptake in the community. There is a group of our population who will need our special attention to vaccinate. They are the healthcare workers, caregivers, the foreign domestic helpers, the immunocompromised, and the pregnant mothers. There are many areas we need to work on to improve our vaccination rate. Primary Care Research will provide the evidence and guide the refinement of these programmes.