The objectives of this review are to provide an update on medical ethics in the context of vaccinations. Vaccinations are effective solutions of controlling vaccine preventable infections. However, like any medication, they have the potential of causing minor adverse effects. Also, such adverse effects may be blown out of proportion if the myths and misconceptions remain unchallenged with evidenced information. The result will be a growing distrust to anyone advocating vaccination. The new ethical strategy is to deal with vaccine rejecter and vaccine hesitant respectfully. It is ethically incorrect to view vaccine sceptics as ill-informed or less educated individuals. By maximizing the opportunities for engagement and discussion of patient or parental vaccine concerns, the potential for a change in decision making towards vaccine acceptance is big. In acute humanitarian emergencies - the 3 Rs – rationing, restrictions, and responsibilities – provide a framework for rapid correct ethical decision making.