There are significant health concerns faced by persons with intellectual disability (PwID) in Singapore, who experience higher rates of morbidity and mortality compared to the general population. PwID encounter various health challenges, yet despite the increased risk of chronic diseases, they are screened less. Moreover, as PwID live longer, new challenges emerge, including complications of chronic disease, and ageing-related conditions. Currently, there are no standardised guidelines for health screening for PwID, and applying regular principles of health screening to this population presents challenges. Individualised approaches are recommended based on needs, risk factors, and severity of intellectual disability. This article presents recommendations for health screening based on a Singapore charity’s experience of caring for PwID, as well as useful accommodations that might increase the success of health checkups for PwID. We also detail specific recommendations for screening of adults with Down Syndrome. Addressing the specific healthcare needs of PwID is crucial for improving their well-being and longevity.