Singapore remains vulnerable and receptive to the reintroduction of malaria despite being declared malaria free by the WHO since 1982.1,2 Nonetheless, local outbreaks have taken place due to importation of patients/workers with malaria from their travels overseas.3 In 2009, an outbreak in Sembawang and Mandai were detected from the clusters of Anopheles mosquitoes.4 Malarial drug resistance is now widespread among the world. Chloroquine prophylaxis is no longer sufficient for their travel to endemic malarial regions. As family physicians our role is to advise our patients on their need to take effective chemoprophylaxis for their travels overseas, and be vigilant for patients suffering from possible malaria especially those back from their travels. As anopheles mosquito is still indigenous in Singapore, we should consider doing a malaria workup for those patients presenting with fever of unknown origin, despite their lack of recent travel. This paper gives a an update of the current - local epidemiological data. - the unique features of the various plasmodium species in Singapore - the current state of drug resistance against malatia drugs, how it affects thechemoprophylaxis and brief discussion on the prevention and management of patients with malaria