Oral health is an integral component of general health and wellbeing. It is essential even in old age. This article describes the common medical conditions which can influence the oral health of the elderly. Xerostomia (dry mouth) may be the effect of medications. Reduced salivary flow not only increases the risk of dental caries. It also affects complete denture retention and is associated with increased periodontal disease, burning, or soreness of the oral mucosa. Periodontitis is one of the complications of diabetes mellitus. Furthermore, periodontitis may be a risk factor in the development of cardiovascular disease. The oral manifestations of the complications of radiotherapy to the head and neck region are directly related to the dose intensity. cancer of the mouth and pharynx is among the top 10 most common cancers for both men and women. The initial signs of oral cancer commonly involves a non-healing ulcer with indurated, irregular edges, commonly on the tongue, lip and floor of mouth. Prior to cardiovascular surgery, it would be helpful to refer patients for dental evaluation and clearance, especially if the patients will be on warfarin or other anti-coagulants post-surgery. Removing all foci of dental infection before starting bisphonphonate theray especially i/v bispohonate therapy will reduce the risk of osteonecrosis of the jaw.