There is currently greater awareness of emerging infections occurring around the world. Increasing human-animal interface over the past decades may explain the origin of such zoonotic agents, and its spread is further perpetuated by climatic changes, vector migration, and international travel and trade in our global village. It is paramount that frontline physicians stay vigilant, as the threat of importation of such diseases via returning travellers as agents with outbreak potential will challenge our healthcare systems and socioeconomic structures, just like how COVID-19 did. It is not sufficient to rely on global public health measures. Individual frontline physicians have a role to play in preventive measures such as pre-travel advice, ensuring vaccinations are up to date, and advocating antimicrobial stewardship. Steps to take during an outbreak include mobilising a response team, ensuring infrastructure is in place, ensuring good communication amongst healthcare workers and patients, and lastly, investing in the training, safety, and welfare of frontline staff.