Advancements in acute stroke management have led to improved mortality rates. However, stroke remains a chronic lifelong condition and is one of the top three leading causes of disability in Singapore. Stroke management typically commences in an acute hospital for acute stabilisation, followed by inpatient rehabilitation and outpatient rehabilitation. With the trend towards early supported discharge of stroke patients, general practitioners (GPs) are crucial in providing comprehensive and evidence based post-stroke care, which includes treating associated cardiovascular comorbidities as well as preventing complications and optimising quality of life. This article aims to provide GPs with current evidence on the use of selective serotonin inhibitors (SSRIs) in post-stroke recovery. It is important for GPs to be aware that post-stroke depression (PSD) is a common complication of stroke and significantly affects mortality and recovery. SSRIs have been commonly used for treatment of PSD. Early phase studies had suggested improvement of post-stroke motor outcomes with the use of SSRIs, although subsequent trials demonstrated conflicting results.