Primary care physicians (PCPs) care for patients from cradle to grave, across multiple disciplines and within the context of the family. They are thus well-placed to provide genomic education and clinical services to their patients in partnership with Genetics Healthcare Professionals (GHPs). However, the specific role of PCPs to support genomic medicine is unclear, and hence a review was conducted to understand the ways PCPs can integrate genomic medicine practices. Materials and Methods: Relevant publications were retrieved from Google Scholar and PubMed using the keywords of “Genomics”, “Primary Care Physicians”, and “Role”. Main results: Thirty-seven retrieved articles provided information that is included in this review. PCPs need to increase their knowledge and understanding of genomics; develop competency in the collection of family histories; have knowledge of the genetic screening tests available; know when to refer their patients for genetic screening; and be able to manage ethical, legal, and social issues that may arise. Conclusion: PCPs play an essential role in the provision of appropriate genomics services, in improving access, in co-managing patients with GHPs, and in providing scientific understanding of genomics to the community.