Pneumonia is the second-most-common cause-of-death in Singapore; vaccination therefore comprises a significant part of Singapore’s strategy to improve population health, and is embedded into primary care at the national level through Healthier SG. Tropical heat and humidity in Singapore predisposes to year-round transmission of respiratory-viral-infection (RVIs), including COVID-19, influenza, and respiratory-syncytial virus (RSV). The list of vaccine-preventable respiratory infections has expanded beyond influenza and pneumococcal vaccination in recent years to include COVID-19 and RSV; however, vaccine-hesitancy is a major obstacle to vaccination uptake and prevention of respiratory infections. Familiarity with the various vaccine-preventable respiratory diseases is essential for the primary care physician.