The Singapore Family Physician
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Vol 37 No. 4 - Cardiometabolic Risk Update
Rationale for Combination erapy in Lipid Management Strategy
The Singapore Family Physician
Vol 37
No 4
- Cardiometabolic Risk Update
14
- 17
1 October 2011
0377-5305
Due to the increasing prevalence of obesity and Type II diabetes mellitus (DM), mixed dyslipidemia characterised by high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) and small dense low-density lipoprotein cholesterol (LDL-C) particles is becoming increasingly common 1.
The primary goal of lipid treatment is to reduce LDL-C to target levels. However, residual cardiovascular risk remains even after achievement LDL-C goal in high risk patients on statin treatment.
This residual risk may be due in part to persistently low HDL-C and high TG. Combination therapy of statins with fibrates, niacin or prescription omega-3 fatty acids may reduce this risk.